Rail Diagnostics Based on Ultrasonic Guided Waves: An Overview

Rail tracks undergo massive stresses that can affect their structural integrity and produce rail breakage. The last phenomenon represents a serious concern for railway management authorities, since it may cause derailments and, consequently, losses of rolling stock material and lives. Therefore, the activities of track maintenance and inspection are of paramount importance. In recent years, the use of various technologies for monitoring rails and the detection of their defects has been investigated; however, despite the important progresses in this field, substantial research efforts are still required to achieve higher scanning speeds and improve the reliability of diagnostic procedures. It is expected that, in the near future, an important role in track maintenance and inspection will be played by the ultrasonic guided wave technology. In this manuscript, its use in rail track monitoring is investigated in detail; moreover, both of the main strategies investigated in the technical literature are taken into consideration. The first strategy consists of the installation of the monitoring instrumentation on board a moving test vehicle that scans the track below while running. The second strategy, instead, is based on distributing the instrumentation throughout the entire rail network, so that continuous monitoring in quasi-real-time can be obtained. In our analysis of the proposed solutions, the prototypes and the employed methods are described

Deterministic Algorithms for Four-Dimensional Imaging in Colocated MIMO OFDM-Based Radar Systems

In this manuscript, the problem of detecting multiple targets and jointly estimating their spatial coordinates (namely, the range, the Doppler and the direction of arrival of their electromagnetic echoes) in a colocated multiple-input multiple-output radar system employing orthogonal frequency division multiplexing is investigated. It is well known its optimal solution, namely the joint maximum likelihood estimator of an unknown number of targets, is unfeasible because of its huge computational complexity. Moreover, until now, sub-optimal solutions have not been proposed in the technical literature. In this manuscript a novel approach to the development of reduced complexity solutions is illustrated. It is based on the idea of separating angle estimation from range-Doppler estimation, and of exploiting known algorithms for solving these two sub-problems. A detailed analysis of the accuracy and complexity of various detection and estimation methods based on this approach is provided. Our numerical results evidence that one of these methods is able to approach optimal performance in the maximum likelihood sense with a limited computational effort in different scenarios

Novel Deterministic Detection and Estimation Algorithms for Colocated Multiple-Input Multiple-Output Radars

In this manuscript, the problem of detecting multiple targets and estimating their spatial coordinates (namely, their range and the direction of arrival of their electromagnetic echoes) in a colocated multiple-input multiple-output radar system operating in a static or slowly changing two-dimensional or three-dimensional propagation scenario is investigated. Various solutions, collectively called range & angle serial cancellation algorithms, are developed for both frequency modulated continuous wave radars and stepped frequency continuous wave radars. Moreover, specific technical problems experienced in their implementation are discussed. Finally, the accuracy achieved by these algorithms in the presence of multiple targets is assessed on the basis of both synthetically generated data and of the measurements acquired through three different multiple-input multiple-output radars and is compared with that provided by other methods based on multidimensional Fourier analysis and multiple signal classification

An Approximate Maximum Likelihood Method for the Joint Estimation of Range and Doppler of Multiple Targets in OFDM-Based Radar Systems

In this manuscript, an innovative method for the detection and the estimation of multiple targets in a radar system employing orthogonal frequency division multiplexing is illustrated. The core of this method is represented by a novel algorithm for detecting multiple superimposed two-dimensional complex tones in the presence of noise and estimating their parameters. This algorithm is based on a maximum likelihood approach and combines a single tone estimator with a serial cancellation procedure. Our numerical results lead to the conclusion that the developed method can achieve a substantially better accuracy-complexity trade-off than various related techniques in the presence of closely spaced targets

Deterministic Signal Processing Techniques for OFDM-Based Radar Sensing: An Overview

In this manuscript, we analyze the most relevant classes of deterministic signal processing methods currently available for the detection and the estimation of multiple targets in a joint communication and sensing system employing orthogonal frequency division multiplexing. Our objective is offering a fair comparison of the available technical options in terms of required computational complexity and accuracy in both range and Doppler estimation. Our numerical results, obtained in various scenarios, evidence that distinct algorithms can achieve a substantially different accuracy-complexity trade-off

Balanced Propofol Sedation in Patients Undergoing EUS-FNA: A Pilot Study to Assess Feasibility and Safety

Introduction and aims. Balanced propofol sedation (BPS) administered by gastroenterologists has gained popularity in endoscopic procedures. Few studies exist about the safety of this approach during endosonography with fine needle aspiration (EUS-FNA). We assessed the safety of BPS in EUS-FNA. Materials and methods. 112 consecutive patients, referred to our unit to perform EUS-FNA, from February 2008 to December 2009, were sedated with BPS. A second gastroenterologist administered the drugs and monitorized the patient. Results. All the 112 patients (62 males, mean age 58.35) completed the examination. The mean dose of midazolam and propofol was, respectively, of 2.1 mg (range 1–4 mg) and 350 mg (range 180–400). All patients received oxygen with a mean flux of 4 liter/minute (range 2–6 liters/minute). The mean recovery time after procedure was 25 minutes (range 18–45 minutes). No major complications related to sedation were registered during all procedures. The oxygen saturation of all patients never reduced to less than 85%. Blood systolic pressure during and after the procedure never reduced to less than 100 mmHg. Conclusions. In our experience BPS administered by non-anaesthesiologists provided safe and successful sedation in patients undergoing EUS-FNA

Disease-Modifying Therapies and Coronavirus Disease 2019 Severity in Multiple Sclerosis

Objective: This study was undertaken to assess the impact of immunosuppressive and immunomodulatory therapies on the severity of coronavirus disease 2019 (COVID-19) in people with multiple sclerosis (PwMS). Methods: We retrospectively collected data of PwMS with suspected or confirmed COVID-19. All the patients had complete follow-up to death or recovery. Severe COVID-19 was defined by a 3-level variable: mild disease not requiring hospitalization versus pneumonia or hospitalization versus intensive care unit (ICU) admission or death. We evaluated baseline characteristics and MS therapies associated with severe COVID-19 by multivariate and propensity score (PS)-weighted ordinal logistic models. Sensitivity analyses were run to confirm the results. Results: Of 844 PwMS with suspected (n = 565) or confirmed (n = 279) COVID-19, 13 (1.54%) died; 11 of them were in a progressive MS phase, and 8 were without any therapy. Thirty-eight (4.5%) were admitted to an ICU; 99 (11.7%) had radiologically documented pneumonia; 96 (11.4%) were hospitalized. After adjusting for region, age, sex, progressive MS course, Expanded Disability Status Scale, disease duration, body mass index, comorbidities, and recent methylprednisolone use, therapy with an anti-CD20 agent (ocrelizumab or rituximab) was significantly associated (odds ratio [OR] = 2.37, 95% confidence interval [CI] = 1.18\u20134.74, p = 0.015) with increased risk of severe COVID-19. Recent use (<1 month) of methylprednisolone was also associated with a worse outcome (OR = 5.24, 95% CI = 2.20\u201312.53, p = 0.001). Results were confirmed by the PS-weighted analysis and by all the sensitivity analyses. Interpretation: This study showed an acceptable level of safety of therapies with a broad array of mechanisms of action. However, some specific elements of risk emerged. These will need to be considered while the COVID-19 pandemic persists. ANN NEUROL 2021;89:780\u2013789

Nippostrongylus-induced intestinal hypercontractility requires IL-4 receptor alpha-responsiveness by T cells in mice

Gut-dwelling helminthes induce potent IL-4 and IL-13 dominated type 2 T helper cell (T H 2) immune responses, with IL-13 production being essential for Nippostrongylus brasiliensis expulsion. This T H 2 response results in intestinal inflammation associated with local infiltration by T cells and macrophages. The resulting increased IL-4/IL-13 intestinal milieu drives goblet cell hyperplasia, alternative macrophage activation and smooth muscle cell hypercontraction. In this study we investigated how IL-4-promoted T cells contributed to the parasite induced effects in the intestine. This was achieved using pan T cell-specific IL-4 receptor alpha-deficient mice (iLck cre IL-4Rα −/lox ) and IL-4Rα-responsive control mice. Global IL-4Rα −/− mice showed, as expected, impaired type 2 immunity to N. brasiliensis . Infected T cell-specific IL-4Rα-deficient mice showed comparable worm expulsion, goblet cell hyperplasia and IgE responses to control mice. However, impaired IL-4-promoted T H 2 cells in T cell-specific IL-4Rα deficient mice led to strikingly reduced IL-4 production by mesenteric lymph node CD4 + T cells and reduced intestinal IL-4 and IL-13 levels, compared to control mice. This reduced IL-4/IL-13 response was associated with an impaired IL-4/IL-13-mediated smooth muscle cell hypercontractility, similar to that seen in global IL-4Rα −/− mice. These results demonstrate that IL-4-promoted T cell responses are not required for the resolution of a primary N. brasiliensis infection. However, they do contribute significantly to an important physiological manifestation of helminth infection; namely intestinal smooth muscle cell-driven hypercontractility